Pregnancy with hypothyroidism and its adverse pregnancy outcomes

Background: Thyroid disorders are among the common endocrine disorders in pregnant woman after diabetes mellitus. Pregnancy is a stress test of maternal thyroid function. Several changes are observed in maternal thyroid function during pregnancy and failure to adapt to these physiological changes results in thyroid dysfunction. Subclinical hypothyroidism occurs in 10% of all pregnancies. Hypothyroidism has adverse effects on mother and fetus like anemia, pre eclampsia, preterm delivery, low birth weight and mental retardation of neonate. Decreased availability of thyroid hormones also impair neurological and intellectual development of the fetus. The relevance of this study is to document the association of hypothyroidism and its adverse effects on mother and fetus. Materials and methods: This prospective observational study was carried out during the period January 2020 to December 2020 (12 months) at Government General Hospital (GGH), Rangaraya Medical College, Kakinada, Andhra Pradesh, India. Subjects of this study were 170 antenatal women in third trimester with singleton pregnancy admitted in the obstetric ward, and informed consent was obtained. Women were chosen irrespective of age, parity, residence and socioeconomic status. Women with multiple pregnancy, a known case of thyroid disorder, or any pre-existing medical disorder were excluded. Routine hematological parameters and estimation of T3, T4 and TSH was conducted. Results: In this study out of 170 cases, anemia was seen in-15.29%, pre eclampsia in-11.77%, GDM in-4.11%, Oligohydramnios with IUGR in-5.88%, preterm labor in-3.53%, LSCS in-35.29% and IUFD in-0.59% of case and low birth weight (8.24%), Hyperbilirubinemia (3.53%) and NICU admissions (11.76%). Conclusion: This Study concluded that hypothyroidism in pregnancy leads to preeclampsia, preterm labour, increases caesarean delivery, low birth weight and hyperbilirubinemia in neonates. Henceeffective treatment of hypothyroidism ensures safe pregnancy with minimal maternal and foetal complications.

Modelos de assistência e taxa de parto cesáreo/vaginal em hospitais com diferentes tipos de gestão: uma análise de 2558496 partos / Assistance models to parturition and cesarean rate in hospitals with different types of management: an analysis of 2558496 parturition

Objetivo: Descrever a tendência temporal no Município de São Paulo do parto cesáreo em relação ao parto vaginal, e sua distribuição por maternidades de diferentes tipos de gestão (pública, privada ou ensino/escola) a partir da observação dos dados do Sistema de Informação de Nascidos Vivos - SINASC. Métodos: trata-se de estudo descritivo, retrospectivo, com utilização de fonte secundária de dados, tendo como alvo os partos ocorridos em maternidades com gestão pública, privada e ensino/escola do Município de São Paulo. A casuística referiu-se à totalidade dos partos ocorridos entre os anos de 2003 e 2018. Foi proposto o cálculo da relação de partos cesáreos sobre os partos vaginais. Utilizou-se a Análise de Variância de Kruskall-Wallis com a finalidade de comparar as relações de partos cesáreos/vaginais de acordo com a gestão hospitalar. Resultados: a amostra se totalizou em 2.559.496 partos, sendo que a proporção de partos cesáreos foi de 31,7% (pública), 84,1% (privada) e 36,6% (ensino/escola), respectivamente. A relação de partos cesáreos/vaginais foi de 0.58 na gestão pública, 5.40 na gestão privada e 0.47 na gestão escolar (p<0,0001*). Quanto a mudança anual da taxa de parto cesáreo/vaginal observou-se uma relação temporal similar entre os anos de 2003 e 2018 [pública (0.40-0.51); privada (4.6-6.6); Escola/ensino (0.55-0.60)]. Conclusões: A relação parto cesário/ vaginal se diferenciou nas instituições com gestão pública e de ensino/escola da instituição privada (ocorre 10 vezes mais parto cesáreo nas instituições privadas) apresentando pequena variação neste cenário ao longo dos anos.

Objective: To describe the temporal trend in the city of São Paulo of cesarean delivery in relation to vaginal delivery, and its distribution among maternity hospitals of different types of management (public, private or teaching / school) from the observation of data from the Information System of Live Births - SINASC. Methods: This is a descriptive, retrospective study using a secondary data source, targeting deliveries in public, private and teaching / school maternity hospitals managed in the city of São Paulo. The series referred to all deliveries that occurred between 2003 and 2018. It was proposed to calculate the ratio of cesarean deliveries to vaginal deliveries. Kruskall-Wallis analysis of variance was used to compare cesarean / vaginal birth ratios according to hospital management. Results: the sample totaled 2,559,496 deliveries, and the proportion of cesarean deliveries was 31.7% (public), 84.1% (private) and 36.6% (teaching / school), respectively. The ratio of cesarean / vaginal deliveries was 0.58 in public management, 5.40 in private management and 0.47 in school management (p <0.0001 *). Regarding the annual change in cesarean / vaginal rate, a similar temporal relationship was observed between 2003 and 2018 [public (0.40-0.51); private (4.6-6.6); School / teaching (0.55-0.60)]. Conclusions: The relationship between cesarean section and vaginal delivery differed in publicly and teaching / school institutions of the private institution (there are 10 times more cesarean section in private institutions), showing little variation in this scenario over the years.

Impact Of Patwardhan 'S Technique On Maternal And Fetal Outcome In Second Stage Cesarean Section

Background: Caesarean section at full dilatation with deeply engaged head in the pelvis can be associated with increased maternal and perinatal morbidity .The objective of present study is to compare the maternal and perinatal morbidity between the Patwardhan′s technique and the routine “push” and “pull” method for extraction of the fetus in second stage caesarean. Method: It is retrospective study including 100 cases of caesarean section performed for obstructed labor in between January 2017 to June 2018 in Obstetrics/Gynae Department,Mahatma Gandhi Memorial Medical College Hospital, Jamshedpur, Jharkhand. All the cases were divided into two groups: group A-where baby delivered by the Patwardhan′s technique and group B- where baby delivered by “push” and “pull” method. Maternal morbidity in terms of uterine extensions, PPH, need for blood transfusions as well as neonatal morbidity was compared between two techniques. Result: Review of 100 patients shows that there was significant low rates of maternal morbidity in terms of uterine incision extensions, and other related complications with Patwardhan′s technique. However there was no difference in neonatal outcome in both the groups. Conclusion: The Patwardhan′s technique is superior and quite safe method for delivery of baby in second stage cesarean sections and has minimal complications if anticipated and done skillfully

Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil / Indução de parto utilizando misoprostol em um hospital terciário no sudeste do Brasil

Abstract Purpose To assess cases of labor induction with vaginal 25-μg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-μg tablets ofmisoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β = 0.23, p < 0.001, for a Bishop score of 4 and 5, and β = 0.22, p < 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-μg tablets of misoprostol.

Resumo Objetivo Avaliar os casos de indução do trabalho de parto com misoprostol 25 mcg por via vaginal e seus desfechos maternos em um hospital terciário do Sudeste do Brasil. Métodos Realizou-se um estudo retrospectivo de coorte com 412 gestantes com indicações para indução de trabalho de parto. A indução do trabalho de parto foi realizada com misoprostol 25 mcg vaginal em gestantes com índice de Bishop < 6. Realizou-se análise de regressão stepwise para identificar os fatores presentes ao início da indução que poderiam ser usados como prognosticadores do sucesso da indução do trabalho de parto. Resultados A indução de trabalho de parto determinou 69% de partos normais, sendo que 31% evoluíram para cesárea. Em relação ao número de comprimidos de misoprostol, 1 ou 2 comprimidos foram utilizados em 244 pacientes (59,2%). Das 412 pacientes, 197 (47,8%) necessitaramde ocitocina após a indução commisoprostol para dar continuidade ao trabalho de parto. Na análise de regressão stepwise, apenas a presença de índice de Bishop 4 e 5 e parto vaginal prévio foram fatores independentes com significância estatística na predição do sucesso da indução emobter parto vaginal (β = 0,23, p < 0,001, para índice de Bishop 4 e 5, e β = 0,22, p < 0,001, para parto vaginal prévio). Conclusão Maiores índices de Bishop e parto vaginal prévio são os maiores prognosticadores do sucesso de indução de trabalho de parto com misoprostol 25 mcg vaginal.

Intra-operative complications increase with successive number of cesarean sections: Myth or fact?

OBJECTIVE: To determine whether complications related to surgery increase with increasing number of cesarean sections (CSs) in upper segment placenta. To compare the complications in urgent and elective high order (4-6) repeat CSs. METHODS: A retrospective analysis of 519 women who underwent repeat CS was performed from January to December 2012. Women were divided into 3 groups: group 1 with previous 3 CS (n=325), group 2 with previous 4 CS (n=139), and group 3 with previous > or =5 CS (n=55). RESULTS: Statistically significant differences (P < 0.001) were observed among 3 groups, regarding mean gravidity, type of CS, midline incision and bilateral tubal ligation performed. The risks of severe intra-peritoneal adhesions, thin out lower uterine segment and bladder injury were significantly increased (P < 0.001) with increasing number of CS deliveries. Only one cesarean hysterectomy was done in group 1 due to post partum hemorrhage. No significant differences were found in blood loss, duration of surgery, post operative hospital stay as well as birth weight and Apgar scores of newborns. The elective and emergency CS groups of high order repeat CS had no remarkable differences in operative, post operative complications and fetal outcome. CONCLUSION: Women with repeat CS are at increased risk of having multiple intra-operative surgical complications which increase with each subsequent CS. Pregnant women must be informed of the related risks which may affect counselling regarding possible tubal ligation.Women with repeat CS are at increased risk of having multiple intra-operative surgical complications which increase with each subsequent CS. Pregnant women must be informed of the related risks which may affect counselling regarding possible tubal ligation.

Partos cesáreos e a escolha da data de nascimento no Município de São Paulo / Caesarean sections and the choice of date of birth in the Municipality of São Paulo, Brazil

O Brasil tem uma das maiores taxas de partos cesáreos do mundo, e esse valor tem aumentado anualmente. O presente estudo teve como objetivo analisar possíveis mudanças na data de nascimento decorrentes desse aumento. Foram obtidos os dados dos 1.933.137 nascidos vivos ocorridos no Município de São Paulo entre 2001 e 2010, divididos segundo tipo de parto e data exata de nascimento. Em 2001, a taxa de cesarianas foi de 48,9%, passando a 56,8% em 2010. O dia da semana com menor número de nascimentos (domingo) aumentou a diferença em relação aos outros dias de 111,4 (IC95%: 101,7 - 121,0) em 2001 para 143,1 (IC95%: 135,0 - 151,3) em 2010. Os dois dias com menos nascimentos (Natal e Dia de Finados), apresentaram diferença estatisticamente significativa em relação aos outros dias do ano (p < 0.05) durante praticamente todo o período (a exceção foi o Dia de Finados em 2009). A data com o maior número de nascimentos (Dia Internacional da Mulher) apresentou diferença significativa em 2005 e 2010. O aumento no número de partos cesáreos tem tido efeito significativo na data de nascimento, o que pode trazer consequências no planejamento administrativo de instituições de saúde.

Brazil has one of the highest rates of cesarean births, and the number has been growing annually. The scope of this study was to test the possible consequences arising from this increase on the date of birth. The 1,933,137 live births that occurred in São Paulo, Brazil, from 2001 to 2010 were analyzed by type of delivery and exact date of birth. In 2001, 48.9% of all births were by cesarean section, increasing to 56.8% in 2010. During th is period, the difference between the number of births occurring on Sundays (the day of the week with the lowest number) increased from 111.4 (95%CI: 101.7 - 121.0) in 2001, to 143.1 (95%CI: 135.0 - 151.3) in 2010. The two dates with the lowest number of births (Christmas day and the Day of the Dead), had a statistically significant (p < 0.05) difference from the other days of the year during most of the period (the exception being the Day of the Dead in 2009). The date with the highest number of births (International Women's Day) showed a statistically significant d ifference in 2005 and 2010. The increase in the number of cesarean births has had a significant impact on date of birth, which could have consequences for the administrative planning of health institutions.

Features and Characteristics of the Maternal Coagulation System During Cesarean Sections / Монголын Анагаах Ухаан

As Mongolia is one of the countries with a high maternal mortality rate, the main goal of the Ministry of Health is to reduce the maternal mortality rate. According to the 2005 social survey, Mongolias average population growth reached 1.5 percent and 50.4 percent of the population are females including those of reproductive age making up 28.3 percent. Health and sociological surveys conducted in recent years have shown that the number of multiparae and multigravidae is unlikely to fall in the coming years, probably in the next 10 years. The lack of studies of hemostasia and hemodynamic in multiparae who underwent Cesarean sections has served as the grounds for this research. Goal The goal of this research is to develop a method of preventing surgical complications by studying the causes and characteristics of Cesarean sections in multiparae. Objectives: 1. To do a comparative study of changes in hemodynamic and hemostasia before, during, and after Cesarean sections and process the results, 2. To evaluate laboratory test results during Cesarean sections in multiparae. Methodology 1. Research Materials: Analysis materials are the laboratory samples and birth histories of mothers having Cesarean sections. 2. Research Methodology 3. Sampling Frame: The study will involve mothers (approximately 70 mothers) who are hospitalized in Maternal Departments 1 and 2 of the Clinical Maternity Hospital No. 1 and who will be delivered of their children by Cesarean sections. 4. To study the characteristics of Maternal Coagulation System and to do a selective comparison to the result. Results We have made an analysis to determine the indicators of the erythrocytes and coagulation systems before, during, and after sections in order to study the changes taking place in hemodynamic and hemostasia for discovering the changes in the coagulation systems of multiparae. Our research has identifi ed the following indicators of coagulation: clotting time, activated decalcifi cation time, artifi cially activated thromboplastin time, and fi brinogen amount. Each indicator of the test takes part in a particular stage of clotting and indicates failure of clotting factors or dysfunction of particular stages. According to the analysis, the clotting time in multiparae accelerates 1.5 times more than in prima gravidae, creating over clotting of blood. It indicates that the members of this group should be included in a group with a high risk of thromboembolism. The average level of the artifi cially activated thromboplastin time in prima gravidae was 32.24.6 before sections, 32.74.8 during sections, and 383.4 on the second day after sections, while multiparae had 39.73.4 seconds before sections, 37.34.4 seconds during sections, and 35.73.4 seconds on the second day after sections. It shows that these two indicators have no dramatic changes in prima gravidae, but they are shortened in multiparae during all stages of sections, proving a risk of thromboembolism. During normal pregnancy, both fi brinogen and its procoagulant level increase, reaching the maximum level before delivery, and therefore, the protein level is usually high during normal pregnancy. That is to say, changes in the coagulation system are directly dependent (P=0.01). Discussion Some Mongolian researchers who have studied the coagulation system disorders concluded that all indicators of clotting reach their maximum levels at the end of pregnancy and cause over clotting of blood through adaptation mechanisms.Our study has shown that these women have certain infl ammations or clotting disorders, since their pregnancy continues together with obstetrical or system disorders. During our research, the tests for the artifi cially activated thromboplastin time and the activated recalcifi cation time have determined the over clotting of blood, in particular the activity of the internal tract of hemostasia, and identifi ed a risk of thromboembolism. These results are similar to those of the studies conducted by A.Ts. Makatseriya (1997), and Sh.Sh. Rajabova (1997), and other scientists of the Dagestan University. Conclusion 1. Compared to those in the prima gravidae who had Cesarean sections, the artifi cially activated thromboplastin time and the activated recalcifi cation time in the multiparae who have had Cesarean sections fall signifi cantly (P=0.01), and this proves a high risk of thromboembolism. The above mentioned two groups have different fi brinogen levels. The fact that the fi brinogen level in the multiparae increases during and after the sections proves that pregnancy continues together with system or obstetrical disorders. 2. Multiparae belong to a high-risk group. If these women receive antenatal care as early as possible and timely complex measures are taken to reveal and cure system disorders in the mothers and normalize the changes taking place in hemodynamics and hemostasia. It is possible to prevent potential complications during or after sections and reduce maternal and fetal mortality rates.